Digital technology is ubiquitous in the lives of children and youth. Their interactions with the digital landscape are embedded in a complex system involving peers, parents, schools, and the larger world. In addition, technology and digital media are changing rapidly. The ways in which youth engage with these media today may not be the way they will engage a year from now. Thus, addressing health, safety, and privacy concerns for youth online must involve an on-going, whole-of-society approach in which industry, parents and caregivers, schools, health providers, other community-based organizations, and policymakers play their roles, informed by insights from a robust research community, and from engaging with youth voices.